[Kasarda]

I drafted 3 Horde of Notions and got to play one of them every single match!  It was great, I would be like well 5 mana bring back Shriekmaw, Nameless Inversion, Faultgrinder, Nova Chaser.  They just kept coming around and nobody wanted them.  I also got 3 Fertile Grounds so that helped a lot.  Pretty Funny.

[leesteht]

I was just testing with some hombres and we discovered a pretty fun/awesome Elementals build with Horde

[Lythand]

My best move in a game was in the 1999 regionals. I was playing a Replenish deck, and playing against a Yawgmoth's bargain deck. My opponant played a yawgmoth's bargain. I cast an Erase on the Bargain and he attempts to go off by drawing cards, only to "run out of gas". My turn I cast a Replenish and take away the tempo and finish him off the turn after that. He was so mad and I was very excited. It had been the best I had did in a major tournament at that time.

[Skyblast2]

I was playing a really good burn deck, and i knew the guy had a fireball in his hand. I had a counterspell, Bob, and a prismatic lens, i had 6 mana and taped 5 to play Bob and the Prismatic lens. That's ok if you have more than 10 life, to my dismay i had 4 life. I died next turn 

[GodZola]

my Moonlace combo deck...

that was not a good move...

[leesteht]

My 1999 Regionals I faced a really good player, playing the same deck I was playing Necropotence. He won the die roll so he won game 1 I won game 2.

Game 3 he 1st turn Necropotence subsequently destroying my lands as I laid them. He waited to drainlife me to bring me to 1 so he necro'd himself to 3 so he could get the next land on his next turn. I laid a swamp cast dark ritual dark ritual drained him for 3 for the win. On that day, I went 16-0-1 to become the 1999 Southeast Regional Champion

[contra-coup]

Incredible.  3 Hordes in a draft AND nova chaser AND shriekmaw AND Inversion?!  Was this an FNM?  Nobody liked good cards?

Not really a "best move" for you but rather a "worst move" for everyone else.

[Wolfstalker]

ummm i played sealed last FNM.  He had 19 life due to life gain with divinity of pride and i had 2 life left.  I topdecked an unwilling recruit and i was like "OH SNAP!"  I played unwilling recruit on his divinity of pride that also had an edge of divinity on it.  I then used 3 mana to pump it to a massive 10/7 flyer with lifelink.  Then i cast double cleave on it and swung a life swing bringing him to 0 and me to 22 life   He was like like WTF! he just stared at the table for a minute in shock!  haha, gotta love those times    apparently that happens to Lee alot cuz he is lucky and topdecks like a maniac

[GodofRoads]

I was playing a Black/White deck and not doing too hot in the first couple of rounds at FNM. I was playing against elves and he had annihilated my side of the field. but I had a Light from Within on the table and topdecked a Divinity of Pride. YES, so now I had a 9/9 FLyer with Lifelink on the field and swung in with that. That brought me above 25 life so I was up to a 13/13 with flying. Next turn I draw and Armored Ascension and plop it on the field to bring my Divinty to a 19/19 flyer with lifelink. IT WAS GREAT.

The week before with that deck I was in my final match and my oppenent just played 2 Spectral Processions . I had 2 edge of Divinitys in My hand, but no creatures to play them, things are looking real bad for me. I topdeck Voracious Hatchling, drop him and play both edges, removing all counters and pumping him into a 12/12 with lifelink. I keep swinging with him, and eventually get my life total somewhere well over 70 by the time he runs out of chump blockers. It was insane. And really fun.

I also had an awesome Eventide release sealed event where-in I got Divinity of Pride, 2 Nightsky Mimics a Deathbringer Liege, 3 unmakes, and an Incremental Blight.  Plus a lot of just really solid white aggro creatures. Its like the cards were begging me to play Black/White that week. Man that deck was fun.

As for Worst move, trying my scarecrow combo deck with no real playtesting. Turns out it isn't good against burn. Or Aggro. Or Control. Or anything.